Red Tier

Wolf 10

TB-500 (Thymosin Beta-4)

Research-use-only peptide studied for cytoskeletal signaling, cell motility, and matrix remodeling in tissue-function models.

  • Assesses tissue remodeling pathways.
  • Explores angiogenic signaling models.
  • ≥99% Pure | 5X Tested | PhD-Formulated | GMP/ISO

In stock

$100.00

Description

TB-500 (Thymosin Beta-4) | Introduction

TB-500 refers to research-grade thymosin β4 (timbetasin), used in RUO models to probe cytoskeletal signaling, motility, and matrix remodeling. Typical readouts include actin dynamics, focal-adhesion markers, and migration/closure assays. Not intended for diagnostic or therapeutic use.

  • Actin-binding/cytoskeletal signaling
  • Cell migration & wound-closure models
  • Matrix deposition and remodeling markers
NameTB-500 (Thymosin Beta-4; Thymosin β4 Acetate)
SynonymsThymosin β4; Timbetasin; Tβ4; TB-500
SequenceAc-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Molecular FormulaC212H350N56O78S
Molecular Weight~4963.5 g/mol
CAS Number77591-33-4
AppearanceWhite to off-white lyophilized powder
SolubilitySoluble in sterile or bacteriostatic water
Purity≥99% (HPLC), lot-specific
Storage Guidelines• Lyophilized: ≤0°F (–18°C), dry, protected from light/moisture
• Reconstituted: 36–46°F (2–8°C); short-term only
• Long-Term: Store dry at ≤−20°C; avoid freeze–thaw
  • Purity & Identity: ≥99% | HPLC & MS validated
  • Endotoxin & Sterility: <0.05 EU/mg | Third-party verified
  • Stability & Process: Controlled-nucleation lyophilization | Stability-focused procedures
  • Formulation & QA: PhD-formulated | GMP / ISO-aligned manufacturing
  • Packaging: Luxe Fridge-Ready Box

Tissue-remodeling peptides are used in RUO systems to study how cells organize cytoskeleton and matrix—migration, adhesion, and protein-network balance. These models help profile dynamic protein function under strain, injury, or growth conditions.

Exciting Areas of Study

  • Actin turnover, lamellipodia/filopodia dynamics
  • ECM production and deposition assays
  • Motility, closure, and invasion models
  • Cytoskeletal signaling cross-talk (FAK, Rho/ROCK)

Research Applications

  • Quantify migration/closure kinetics in vitro
  • Probe protein–matrix signaling balance
  • Benchmark remodeling signatures vs. controls
  • Map actin-binding effects on cytoskeletal architecture
  • Evaluate matrix remodeling and adhesion markers
  • Compare motility phenotypes across stressors

This product is intended solely for laboratory research purposes. It is not suitable for human, animal, or household use. Researchers must follow institutional safety protocols. See our Terms & Conditions and our Research Compliance Disclaimers for details.

Additional information

Select Strength (MG)

10MG

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Third Party Testing

Lot number Analysis date Testing Certificate
LBL-1125-5AM-1056 February 9, 2026 Purity & Net Peptide Testing View PDF
LBL-0326-10AM-0014 March 27, 2026 Purity & Net Peptide Testing View PDF
LBL-0326-5AM5-0006 May 18, 2026 Purity & Net Peptide Testing View PDF

Knowledge Hub

Research & Education

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    Wolverine 20: BPC-157 & TB-500 Synergistic Tissue Repair Pathways

    Examining the multi-modal angiogenic and cellular migration dynamics when pairing stable gastric pentadecapeptide BPC-157 with actin-sequestering peptide TB-500 in tissue culture and connective tissue assays.

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Browse the Knowledge Hub

  • Testing / COA Education

    Reading Lab Certificates of Analysis (COA): HPLC Traces & Mass Spectrometry

    A practical guide to interpreting analytical test reports: deciphering RP-HPLC chromatograms, understanding baseline integration, verifying electrospray ionization (ESI-MS) molecular mass, and evaluating third-party lab verification.

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    Retatrutide, mots-c
    Last reviewed
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    Read guide: Reading Lab Certificates of Analysis (COA): HPLC Traces & Mass Spectrometry
  • Handling / Storage

    Peptide Reconstitution & Storage: Preserving Lyophilized Cake Stability

    Essential laboratory guidelines for reconstituting lyophilized peptides: selecting diluents, minimizing shear stress during fluid introduction, temperature cycling parameters, and optimal freeze-thaw mitigation.

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    Read guide: Peptide Reconstitution & Storage: Preserving Lyophilized Cake Stability
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    Wolverine 20: BPC-157 & TB-500 Synergistic Tissue Repair Pathways

    Examining the multi-modal angiogenic and cellular migration dynamics when pairing stable gastric pentadecapeptide BPC-157 with actin-sequestering peptide TB-500 in tissue culture and connective tissue assays.

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    bpc-157, tb-500
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    Read guide: Wolverine 20: BPC-157 & TB-500 Synergistic Tissue Repair Pathways
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    Retatrutide (GLP-1 / GIP / Glucagon Tri-Agonist): Molecular Mechanisms & Preclinical Findings

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