Blue Tier
MOTS-c
Research-use-only mitochondria-derived peptide studied for AMPK-linked signaling, metabolic-stress responses, and cellular bioenergetics.
In stock
$159.00
Latest certificate on record
Batch Feb 26 · Apex Labs
MOTS-c is a 16-amino-acid mitochondrial-derived peptide used in RUO bioenergetic models to probe metabolic regulation and stress adaptation. Studies evaluate folate–purine–AMPK pathway interactions, glucose handling, and adaptive gene programs under metabolic stress. Not intended for diagnostic or therapeutic use.
Latest Certificate of Analysis.
View COA history.
| Name | MOTS-c |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.6 g/mol |
| CAS Number | 1627580-64-6 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile or bacteriostatic water |
| Purity | ≥95–99% (HPLC), lot-specific |
| Storage Guidelines | • Lyophilized: ≤0°F (–18°C) to −4°F (−20°C), desiccated • Reconstituted: 36–46°F (2–8°C); short-term only • Long-Term: Store dry at ≤−20°C; avoid freeze–thaw |
Bioenergetic peptides are used in RUO studies to explore how cells generate, manage, and recover energy. These compounds interact with key metabolic pathways—especially mitochondrial ATP output and redox signaling—making them essential tools for researchers investigating energy dysfunction, oxidative stress, and cell viability under stress conditions.
Exciting Areas of Study
Research Applications
This product is intended solely for laboratory research purposes and is not suitable for human, animal, or household use. Researchers must follow institutional safety protocols. See our
Terms & Conditions and Research Compliance Disclaimers for details.
| Select Strength (MG) | 10MG, 20MG |
|---|
| Batch | Test date | Laboratory | Type | Certificate |
|---|---|---|---|---|
| Feb 26 | 22 Sep 2026 | Apex Labs | Certificate of Analysis |
| Lot number | Analysis date | Testing | Certificate |
|---|---|---|---|
| Feb 26 | September 22, 2026 | Potency, Purity & Identity (HPLC-Peptides) | View PDF |
Knowledge Hub
Guides and reference material related to MotC 20.
Compound Guide
A comprehensive analysis of the 16-amino-acid mitochondrial-derived peptide MOTS-c, detailing AMPK activation, nuclear translocation under metabolic stress, and mitochondrial-nuclear communication in cell culture.
Read guide: MOTS-c: Mitochondrial Biology & Cellular Energy Regulation in Preclinical ModelsTesting / COA Education
A practical guide to interpreting analytical test reports: deciphering RP-HPLC chromatograms, understanding baseline integration, verifying electrospray ionization (ESI-MS) molecular mass, and evaluating third-party lab verification.
Read guide: Reading Lab Certificates of Analysis (COA): HPLC Traces & Mass Spectrometry
Testing / COA Education
A practical guide to interpreting analytical test reports: deciphering RP-HPLC chromatograms, understanding baseline integration, verifying electrospray ionization (ESI-MS) molecular mass, and evaluating third-party lab verification.
Read guide: Reading Lab Certificates of Analysis (COA): HPLC Traces & Mass SpectrometryHandling / Storage
Essential laboratory guidelines for reconstituting lyophilized peptides: selecting diluents, minimizing shear stress during fluid introduction, temperature cycling parameters, and optimal freeze-thaw mitigation.
Read guide: Peptide Reconstitution & Storage: Preserving Lyophilized Cake StabilityComparison
Examining the multi-modal angiogenic and cellular migration dynamics when pairing stable gastric pentadecapeptide BPC-157 with actin-sequestering peptide TB-500 in tissue culture and connective tissue assays.
Read guide: Wolverine 20: BPC-157 & TB-500 Synergistic Tissue Repair PathwaysCompound Guide
A comprehensive analysis of the 16-amino-acid mitochondrial-derived peptide MOTS-c, detailing AMPK activation, nuclear translocation under metabolic stress, and mitochondrial-nuclear communication in cell culture.
Read guide: MOTS-c: Mitochondrial Biology & Cellular Energy Regulation in Preclinical ModelsCompound Guide
An in-depth biochemical review of Retatrutide (LY3437943), examining its multi-target agonist activity at GLP-1, GIP, and glucagon receptors, downstream cAMP accumulation, and energetic homeostasis in laboratory research models.
Read guide: Retatrutide (GLP-1 / GIP / Glucagon Tri-Agonist): Molecular Mechanisms & Preclinical Findings| Batch | Test date | Laboratory | Type | Certificate |
|---|---|---|---|---|
| Feb 26 | 22 Sep 2026 | Apex Labs | Certificate of Analysis |
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